Recurrent benign adrenal pheochromocytomas associated with hemihypertrophy

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Recurrent benign adrenal pheochromocytomas associated with hemihypertrophy

UNLABELLED We report a case of a female with hemihypertrophy, who developed five recurrences of pheochromocytomas until the age of 35. Timely follow-up of the patient's blood pressure assisted in early diagnosis and treatment of recurrent tumors. LEARNING POINTS Recurrent benign pheochromocytomas should raise suspicion of a genetic syndrome.A pheochromocytoma at a young age has a high propens...

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Hepatoblastoma associated with congenital hemihypertrophy.

Congenital hemihypertrophy is an uncommon condition with a reported incidence of 1 in 86,000 live births(l). There is a well documented association of hemihypertrophy with a number of malignant and non-malignant intra-abdominal masses including Wilms' tumor and adrenal cortical neoplasia(2). However, association of hemihypertrophy with hepatoblastoma is an uncommon condition and only two such c...

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Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas.

Pheochromocytomas (PCCs) and extra-adrenal sympathetic paragangliomas (sPGLs) are catecholamine-producing tumors occurring in the context of hereditary tumor syndromes, with known germline mutations, and as sporadic tumors. The pathogenesis of sporadic PCC and sPGL is poorly understood, and little is known about intra-tumoral heterogeneity with respect to molecular aberrations. Since knowledge ...

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Disentangling of Malignancy from Benign Pheochromocytomas/Paragangliomas

OBJECTIVE Many malignant tumors initially appear benign but subsequently exhibit extensive metastases. Early identification of malignant pheochromocytomas and paragangliomas (PPGLs) before metastasis is important for improved prognosis. However, there are no robust prognostic indices of recurrence and malignancy. The aim of this study was to identify the clinical and histopathological factors t...

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Article history: Received: 01 Jan 2011 Revised: 02 Mar 2011 Accepted: 10 Mar 2011

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ژورنال

عنوان ژورنال: Endocrinology, Diabetes & Metabolism Case Reports

سال: 2014

ISSN: 2052-0573

DOI: 10.1530/edm-14-0041